To make this mode as easy as possible you have to loot and collect everything (health, salts, money, ammo, infusions, gear, Voxophones) which means this playthrough will be time consuming, so take your time.Besides that I highly recommend to play the game first in one of the normal difficulty settings to enjoy the story and to get familiar with the weapons, Vigors, upgrades, enemies and overall game mechanics.This guide represents the strategies that I used in my playthrough, I don’t consider them to be best or anything. Second, there are many different ways to beat the game on 1999 difficulty, it mainly depends on your play style and weapon preferences.First, be aware of spoilers, there will be a lot in this guide, you have been warned.